KDA
- Current
- Browse
- Collections
-
For contributors
- For Authors
- Instructions to authors
- Article processing charge
- e-submission
- For Reviewers
- Instructions for reviewers
- How to become a reviewer
- Best reviewers
- For Readers
- Readership
- Subscription
- Permission guidelines
- About
- Editorial policy
Search
- Page Path
- HOME > Search
- Effects of Endurance Exercise and High-Fat Diet on Insulin Resistance and Ceramide Contents of Skeletal Muscle in Sprague-Dawley Rats
- Hyun Lyung Jung, Ho Youl Kang
- Korean Diabetes J. 2010;34(4):244-252. Published online August 31, 2010
- DOI: https://doi.org/10.4093/kdj.2010.34.4.244
- 3,284 View
- 28 Download
- 9 Crossref
-
Abstract
PDF
PubReader Background We evaluated the effects of endurance exercise and a high-fat diet on insulin resistance and ceramide contents of skeletal muscle in Sprague-Dawley rats.
Methods We randomly divided 32 rats into four groups: control (CON,
n = 8), high fat diet (HF,n = 8), exercise (Ex, 24 m/min for 2 hours, 5 days/wk,n = 8), HF/Ex (n = 8). After 4-week treatments, plasma lipid profiles, glucose and insulin concentrations were measured. The triglycerides (TG), ceramide, and glucose transporter 4 (GLUT-4) contents were measured in the skeletal muscle. The rate of glucose transport was determined under submaximal insulin concentration during the muscle incubation.Results Free fatty acid levels were significantly higher in CON and HF than Ex (
P = 0.032). Plasma glucose levels in HF were significantly higher than the two Ex groups (P = 0.002), and insulin levels were significantly higher in HF than in other three groups (P = 0.021). Muscular TG concentrations were significantly higher in HF than CON and Ex and also in HF/Ex than Ex, respectively (P = 0.005). Hepatic TG concentrations were significantly higher in HF than other three groups but Ex was significantly lower than HF/Ex (P = 0.000). Muscular ceramide content in HF was significantly greater than that in either Ex or HF/Ex (P = 0.031). GLUT-4 levels in CON and HF were significantly lower than those in Ex and HF/Ex (P = 0.009,P = 0.003). The glucose transport rate in submaximal insulin concentration was lower in CON than in either Ex or HF/Ex (P = 0.043), but not different from HF.Conclusion This study suggests that high fat diet for 4 weeks selectively impairs insulin resistance, but not glucose transport rate, GLUT-4 and ceramide content in skeletal muscle per se. However, endurance exercise markedly affects the content of ceramide and insulin resistance in muscle.
-
Citations
Citations to this article as recorded by
- Early warning for inactive ovaries based on liver function index, serum MDA, IL-6, FGF21 and ANGPTL8 in dairy cows
Zhijie Wang, Yuxi Song, Feng Zhang, Chang Zhao, Shixin Fu, Cheng Xia, Yunlong Bai
Italian Journal of Animal Science.2022; 21(1): 113. CrossRef - Metabolic Syndrome is Associated with Ceramide Accumulation in Visceral Adipose Tissue of Women with Morbid Obesity
Barbara Choromańska, Piotr Myśliwiec, Hady Razak Hady, Jacek Dadan, Hanna Myśliwiec, Adrian Chabowski, Agnieszka Mikłosz
Obesity.2019; 27(3): 444. CrossRef - Changes in Membrane Ceramide Pools in Rat Soleus Muscle in Response to Short-Term Disuse
Alexey M. Petrov, Maria N. Shalagina, Vladimir A. Protopopov, Valeriy G. Sergeev, Sergey V. Ovechkin, Natalia G. Ovchinina, Alexey V. Sekunov, Andrey L. Zefirov, Guzalia F. Zakirjanova, Irina G. Bryndina
International Journal of Molecular Sciences.2019; 20(19): 4860. CrossRef - Lipids in psychiatric disorders and preventive medicine
Miriam Schneider, Beth Levant, Martin Reichel, Erich Gulbins, Johannes Kornhuber, Christian P. Müller
Neuroscience & Biobehavioral Reviews.2017; 76: 336. CrossRef - A mitochondrial-targeted ubiquinone modulates muscle lipid profile and improves mitochondrial respiration in obesogenic diet-fed rats
Charles Coudray, Gilles Fouret, Karen Lambert, Carla Ferreri, Jennifer Rieusset, Agnieszka Blachnio-Zabielska, Jérôme Lecomte, Raymond Ebabe Elle, Eric Badia, Michael P. Murphy, Christine Feillet-Coudray
British Journal of Nutrition.2016; 115(7): 1155. CrossRef - The Metabolic Implications of Glucocorticoids in a High-Fat Diet Setting and the Counter-Effects of Exercise
Emily Dunford, Michael Riddell
Metabolites.2016; 6(4): 44. CrossRef - Effects of Exercise Intensity on PGC-1α, PPAR-γ, and Insulin Resistance in Skeletal Muscle of High Fat Diet-fed Sprague-Dawley Rats
Hyun-Lyung Jung, Ho-Youl Kang
Journal of the Korean Society of Food Science and Nutrition.2014; 43(7): 963. CrossRef - The roles of aerobic exercise training and suppression IL-6 gene expression by RNA interference in the development of insulin resistance
Hui Tang, Min-hao Xie, Yu Lei, Liang Zhou, Yu-ping Xu, Jian-guang Cai
Cytokine.2013; 61(2): 394. CrossRef - Long-Term Consequences of Developmental Alcohol Exposure on Brain Structure and Function: Therapeutic Benefits of Physical Activity
Anna Klintsova, Gillian Hamilton, Karen Boschen
Brain Sciences.2012; 3(4): 1. CrossRef
- Early warning for inactive ovaries based on liver function index, serum MDA, IL-6, FGF21 and ANGPTL8 in dairy cows
First
Prev
